Restylane Lyft

Perfect Filler for Moderate to Severe Facial Folds and Midface Volume Replacement

Restylane® Lyft, initially approved by the FDA in Spring of 2007 under the name Perlane, is a “mid-dermal” hyaluronic acid filler product. As a sister product to Restylane, Lyft is designed for more pronounced facial folds and cheek and midface volume restoration.

The firm gel is injected into the deep dermis to add volume to help restore surface contour to approximate a younger-aged appearance.

Restylane Lyft corrections maintain volume augmentation for about six to nine months before natural product degradation begins to lessen the effect.

How is Restylane Lyft Different From Restylane?

Both Restylane Lyft and Restylane are composed of hyaluronic acid. The primary difference between Restylane and Lyft is that the hyaluronic acid gel particles in Lyft are larger than those found in Restylane. This gives the filler additional ability to lift and fill the areas of injection that require a denser formulation to hold shape. Lyft and Restylane are perfect complements to one another. For even longer and more defining fillers, meet Restylane Refyne and Defyne.

How Does Restylane Lyft Work?

Restylane Lyft® is an injectable gel designed to lift folds and replace lost facial volume from fat loss, bone loss, and collagen degradation. Lyft’s water-loving nature attracts and binds water molecules to help maintain volume. Watch Live Treatment Restylane Lyft is composed of hyaluronic acid, a natural substance that already exists in the body. The hyaluronic acid in fillers is a crystal clear gel that is chemically cross-linked (the long chemical strands are tied together) to delay breakdown by skin enzymes. All Restylane products are non-animal-based and free from animal protein. This quality prevents disease transmission. Allergy pre-testing is not necessary. Also distinct from other hyaluronic acid dermal fillers, Restylane products are minimally cross-linked, making them similar to the natural hyaluronic acid found in the body. Also view the Restylane Lyft website.

Patient Safety Information



Can Restylane Lyft be Used in Tandem With Other Fillers?

Dr. Pilest finds that most facial correction needs beyond superficial lines will be restored most naturally by the use of product layers. Lyft is the ideal “middle layer” for deep folds. Beginning with Radiesse in the very deep skin layer, Dr. Pilest will add Lyft as a topper – or in many cases, alone if a deeper fill is not yet required.

“Much like the pillow top on a mattress, when used along with Radiesse, Restylane Lyft is supported by the firmer properties of Radiesse while offering a softer upper layer that is extremely natural to the touch.”

For other wrinkles or folds, Lyft may be chosen as the support layer with Restylane, Restylane Silk or Juvederm used as the top product. Depending on the level of correction needed, Dr. Pilest will recommend the most advantageous combination. Patients who find themselves with deep folds and superficial lines may even use three filler layers, such as Radiesse as a base, Restylane Lyft as the pillow top and Restylane Silk or Belotero to smooth the small vertical and smokers’ lines that require placement directly below the uppermost layer of the skin.

Restylane Lyft Before & After Irvine, CA
Restylane Lyft Before & After Irvine, CA

*Individual results may vary.

View More Patient Results


We love our patients at Total Dermatology! Read what our satisfied patients have to say about their experiences with Dr. Pilest and our team.

read more

*Individual Results May Vary

Hyaluronic Acid Background

Hyaluronic acid is a natural complex sugar found throughout all living organisms that retain water — absorbing more than 1,000 times its weight — and adds volume to the skin’s surface. In addition, hyaluronic acid binds with collagen and elastin and transports essential nutrients to these fibers. The triple combination of collagen, elastin and hyaluronic acid provides structure, elasticity, and volume to the skin and contributes to its overall appearance.

As the skin ages and is exposed to environmental pollutants and ultraviolet rays, the cells lose the ability to produce hyaluronic acid. As a result, the skin begins to lose volume, often resulting in the formation of facial wrinkles and folds. Dermal fillers compromised of crossed-linked hyaluronic acid are used by physicians to help temporarily replace lost hyaluronic acid and to restore skin volume and a smooth, natural appearance.

In its natural form, unbound hyaluronic acid forms a liquid made of highly-hydrated individual polymers (chains) that are metabolized in the body in just 12 hours. Cross-linking refers to a process in which the individual chains of hyaluronic acid are chemically bound (or “cross-linked”) together, transforming the liquid hyaluronic acid into a soft solid, or “gel.” The firmness of the gel depends on the degree of cross-linking of the individual hyaluronic acid chains. The body metabolizes cross-linked hyaluronic acid more slowly, resulting in a longer duration of effect when hyaluronic acid is used therapeutically.

Physicians have been developing ways to restore volume and structure to aging skin using a variety of approaches for over 100 years. Past fillers included paraffin, silicone and collagen injections.

In the 1930s, researchers discovered a natural substance in the body that they named hyaluronic acid, and they found that it plays a key role in numerous areas of the body including the maintenance of skin volume and hydration, eye volume and shape and joint lubrication and cushioning.

In the decades since numerous therapeutic and aesthetic uses have been developed for this versatile natural substance. In 2003, the U.S. Food and Drug Administration (FDA) approved the first hyaluronic acid dermal filler for the correction of facial wrinkles and folds, such as nasolabial folds (the folds running from the sides of the bottom of the nose to the outer corners of the mouth).

Today, hyaluronic acid-based dermal fillers are the fastest growing non-invasive aesthetic procedure in the United States, according to the American Society for Aesthetic Plastic Surgery.1
1 American Society for Aesthetic Plastic Surgery. February 24, 2006

Dr. Nissan Pilest is a member of the distinguished Expert Injector collaboration and holds the Circle of Excellence in Soft Tissue Fillers through the American Society of Dermatologic Surgeons. Dr. Pilest performs all injections for dermal fillers and neuromodulators at Total Dermatology.

Pre-treatment Guidelines

Take the First Step – Request A Consultation

Ready to try out EmSculpt NEO® for yourself?

Schedule your consultation with board-certified dermatologist Dr. Nissan Pilest at Total Dermatology in Irvine, CA today by calling (949) 408-1982. 

*Individual Results May Vary