Total Dermatology
Xeomin® Frown & Wrinkle Relaxer2019-04-19T02:55:19-08:00


Softening frown and worry lines

Xeomin is the newest “frown fixer” available to patients across the country. Pronounced zee-oh-min, the new tox product acts like its predecessors Botox and Dysport in reducing or preventing contractions of the glabellar muscle between the eyes.

How is Xeomin different from Botox or Dysport?

The difference in Xeomin (incobotulinumtoxinA) is that it does not carry the proteins that are typical of the other products. The potential advantage lies in the lessened likelihood of antibodies being formed to the proteins which – for a very limited number of patients – can render the product ineffective. (This typically is only seen in patients who have used botulinum toxin for an extended period of time.)

Xeomin before and after femaleResults may vary from patient to patient
See additional Before and After Photos

How is Xeomin similar to Botox or Dysport?

The muscle-restricting action is, for all practical purposes, like Botox and Dysport and the dosing is the same as Botox.

Why would I choose Xeomin?

For some patients there is a slight quicker effect. Patients can frequently use both Dysport and Botox in a single session to achieve desired results. Dr. Pilest does the same with Xeomin. As time goes on, which to choose will be patient preference.

FDA approval of Xeomin

The FDA approval of XEOMIN is based on the results of two pivotal U.S. clinical trials involving 16 investigational sites and included 547 healthy adult patients. In both studies, XEOMIN significantly improved the appearance of glabellar lines 30 days following the first injection, when compared to placebo. XEOMIN is the only botulinum toxin currently approved in the U.S. that does not require refrigeration prior to reconstitution.

“XEOMIN is a promising new option for both patients and physicians and we are encouraged by the response rates seen in the Phase III clinical trials,” said Derek H. Jones, M.D., an investigator for the XEOMIN U.S. study, Clinical Associate Professor of Medicine at the University of California in Los Angeles, Calif., and Director of Skin Care and Laser Physicians in Beverly Hills, Calif.

Xeomin is used in 14 worldwide locations and in the EU under the name Bocouture. As with all botulinum toxins, there are safety warnings that must be made public.

Expert Injector Dr. Nissan PilestDr. Nissan Pilest is a member of the distinguished Expert Injector collaboration and holds the Circle of Excellence in Soft Tissue Fillers through the American Society of Dermatologic Surgeons. Dr. Pilest performs all injections for dermal fillers and neuromodulators at Total Dermatology. About Dr. Pilest


If you would like to learn more about Xeomin® Frown & Wrinkle Relaxer, please call our office at 949-727-3800 today to schedule a consultation or fill out the form on this page and one of our trusted staff members will reach out to you promptly.

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