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PRF Irvine, CA

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The Next Generation of Regenerative Injections

Irvine PRF Treatments

We are no strangers to cosmetic injectables at this point. New treatments promising instant results seem to pop up every day. Platelet-rich fibrin (PRF) is getting a lot of buzz lately, even though it doesn’t offer instant results. Much like a vampire facial, PRF injections use the growth factors in your blood to treat dark circles, wrinkles, and sagging. At Total Dermatology, Dr. Nissan Pilest offers these anti-aging treatments to help you improve your skin health from the inside out in Orange County.

Purely Yours, Nothing Added

What is PRF?

Platelet-rich fibrin (PRF) is a 100% natural treatment made from your own blood that is full of growth factors to build collagen, improve skin quality, and restore volume without any synthetic fillers.

Irvine prf model with black hair

PRF At A Glance

Cost PRF cost is $600 per session; $1,500 for a package of three
Downtime 24–48 hours of social downtime for minor swelling
Pain Level Mild; involves a simple blood draw and local numbing
Duration Results can last 6–12 months after a full series

Precision at Every Angle

What Can PRF Be Used to Treat?

While many patients often think of platelet rich fibrin (PRF) as just an injectable, it is actually a versatile second-generation platelet concentrate that works well on many areas of the face and neck. Most of our patients seeking PRF in Irvine choose this to fix under-eye hollows and dark circles because it helps thicken the thin skin there.

It also works great to add volume back to the cheeks or to soften fine lines and wrinkles, specifically smile lines. We use PRF to smooth out the jawline and temples, or to improve the skin tone and texture of the neck. Beyond facial rejuvenation, this treatment is highly effective for addressing acne scars by triggering the repair process in damaged skin.

Irvine prf model with big hat

The Strength of You

What Are the Benefits of PRF?

The benefits of PRF at our practice center on the fact that it is a completely natural approach to tissue regeneration.

  • No Additives: We don't use any chemicals, thinners, or man-made fillers; we rely solely on the patient's blood.
  • Unlike PRP: While platelet rich plasma (PRP) uses anticoagulants, PRF forms a fibrin matrix that keeps platelets in the treatment area longer.
  • Healing Properties: The higher concentration of white blood cells and stem cells provides a powerful boost to collagen synthesis.
  • Total Safety: Since the procedure uses your own biological material, there are no risks of allergic reactions.

Is Your Skin Ready?

Am I a Candidate for PRF?

PRF treatment is a great choice for almost anyone who wants a natural approach to a youthful glow, but you do need to be in good health for it to work best. We usually find that patients with a medical history of liver disease or certain blood disorders are not a good fit.

Dr. Pilest may also suggest delaying the procedure if you have an active infection at the injection sites. During your consultation, we will review any blood-thinning medications you are taking, as these can affect the healing process. It is important to keep in mind that PRF is for patients who want a gradual improvement rather than an overnight change.

Science in Motion

Your PRF Treatment

The appointment starts with a simple blood draw, just like when you go for a regular checkup. We then put the blood sample in a centrifuge to separate the platelet concentrates from the red blood cells.

The draw feels like a quick, tiny pinch. Because pain tolerance varies, Dr. Pilest or our expert team uses numbing cream so you only feel a little bit of pressure. We then inject the PRF serum into the target areas to jumpstart the natural healing properties of your body. If we are treating hair loss, we focus on the hair follicles to encourage thicker hair and new hair growth.

Quiet Healing, Quick Return

Recovery and Results

You can usually go out to dinner within a day or two, but you might want to wait a little longer for big events. While you can go back to work the same day, you should expect some mild puffiness while the vascular endothelial growth factor begins stimulating new vessel growth. To get the best results, avoid excessive sun exposure immediately following the treatment, as the skin is in a sensitive repair process.

You have to be patient when choosing a natural healing method. While PRP injections might dissipate quickly, the fibrin matrix in PRF allows for platelet activation over a longer period. You will usually see your skin start to improve within several weeks, and the best results show up after three sessions. To maintain your youthful glow, we recommend maintenance treatments every 6 to 12 months.

Decades of Clinical Experience

Why Choose Total Dermatology?

Dr. Nissan Pilest has been a leader in Orange County dermatology since 1979. While many med spas have started offering PRP treatment, we specialize in the second generation of platelet-related biologic features. Our practice stays at the forefront of technological concepts in regenerative medicine, ensuring your personalized treatment plan is backed by the latest clinical data. Whether you are here for cosmetic concerns like wrinkles or more clinical needs like wound healing, we ensure every procedure is performed with medical precision.

Invest in You

Cost of PRF

Pricing for PRF reflects the specialized processing and clinical expertise required for the procedure to be effective. At Total Dermatology, a single session of PRF is $600. To achieve the best regenerative results, we offer a package of three sessions for $1,500. We offer financing through Cherry to keep these treatments accessible.

Your Glow Starts Now

Schedule Your Consultation

Schedule your consultation at (949) 727-3800 or through our Online Booking Link.

PRFFrequently Asked Questions

Yes, it is widely used in sports medicine for tissue damage and in oral surgery for bone graft materials, sinus lifts, or simultaneous implant placement to speed up periodontal regeneration.

Pain tolerance is different for everyone, but most find the injection sites very manageable with our numbing protocols.

A vampire facial usually involves microneedling with PRP, whereas PRF treatment involves deeper injections of a higher concentration of platelets and white blood cells for better tissue regeneration.

The entire procedure, including the blood sample processing and injections, usually takes about 45 to 60 minutes.

Schedule your consultation with Total Dermatology today!

When it comes to your skin and your health, it really is all about what’s best for you. Total Dermatology understands this, which is why we offer versatile treatments with experienced and highly trained aesthetic professionals led by Dr. Nissan Pilest. Your Total Dermatology transformation awaits.

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